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Journal of Biomedical Optics • Open Access

Dual-wavelength retinal images denoising algorithm for improving the accuracy of oxygen saturation calculation
Author(s): Yong-Li Xian; Yun Dai; Chun-Ming Gao; Rui Du

Paper Abstract

Noninvasive measurement of hemoglobin oxygen saturation ( SO 2 ) in retinal vessels is based on spectrophotometry and spectral absorption characteristics of tissue. Retinal images at 570 and 600 nm are simultaneously captured by dual-wavelength retinal oximetry based on fundus camera. SO 2 is finally measured after vessel segmentation, image registration, and calculation of optical density ratio of two images. However, image noise can dramatically affect subsequent image processing and SO 2 calculation accuracy. The aforementioned problem remains to be addressed. The purpose of this study was to improve image quality and SO 2 calculation accuracy by noise analysis and denoising algorithm for dual-wavelength images. First, noise parameters were estimated by mixed Poisson–Gaussian (MPG) noise model. Second, an MPG denoising algorithm which we called variance stabilizing transform (VST) + dual-domain image denoising (DDID) was proposed based on VST and improved dual-domain filter. The results show that VST + DDID is able to effectively remove MPG noise and preserve image edge details. VST + DDID is better than VST + block-matching and three-dimensional filtering, especially in preserving low-contrast details. The following simulation and analysis indicate that MPG noise in the retinal images can lead to erroneously low measurement for SO 2 , and the denoised images can provide more accurate grayscale values for retinal oximetry.

Paper Details

Date Published: 5 January 2017
PDF: 9 pages
J. Biomed. Opt. 22(1) 016004 doi: 10.1117/1.JBO.22.1.016004
Published in: Journal of Biomedical Optics Volume 22, Issue 1
Show Author Affiliations
Yong-Li Xian, Institute of Optics and Electronics (China)
Univ. of Electronic Science and Technology of China (China)
Yun Dai, Institute of Optics and Electronics (China)
Chinese Academy of Sciences (China)
Chun-Ming Gao, Univ. of Electronic Science and Technology of China (China)
Rui Du, Institute of Optics and Electronics (China)
Chinese Academy of Sciences (China)

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