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Journal of Biomedical Optics • Open Access

Wearable near-infrared optical probe for continuous monitoring during breast cancer neoadjuvant chemotherapy infusions
Author(s): Fei Teng; Timothy Cormier; Alexis Sauer-Budge; Rachita Chaudhury; Vivian E. Pera; Raeef Istfan; David A. Chargin; Samuel Brookfield; Naomi Yu Ko; Darren M. Roblyer

Paper Abstract

We present a new continuous-wave wearable diffuse optical probe aimed at investigating the hemodynamic response of locally advanced breast cancer patients during neoadjuvant chemotherapy infusions. The system consists of a flexible printed circuit board that supports an array of six dual wavelength surface-mount LED and photodiode pairs. The probe is encased in a soft silicone housing that conforms to natural breast shape. Probe performance was evaluated using tissue-simulating phantoms and in vivo normal volunteer measurements. High SNR (71 dB), low source-detector crosstalk ( 60    dB ), high measurement precision (0.17%), and good thermal stability (0.22% V rms / ° C ) were achieved in phantom studies. A cuff occlusion experiment was performed on the forearm of a healthy volunteer to demonstrate the ability to track rapid hemodynamic changes. Proof-of-principle normal volunteer measurements were taken to demonstrate the ability to collect continuous in vivo breast measurements. This wearable probe is a first of its kind tool to explore prognostic hemodynamic changes during chemotherapy in breast cancer patients.

Paper Details

Date Published: 13 January 2017
PDF: 8 pages
J. Biomed. Opt. 22(1) 014001 doi: 10.1117/1.JBO.22.1.014001
Published in: Journal of Biomedical Optics Volume 22, Issue 1
Show Author Affiliations
Fei Teng, Boston Univ. (United States)
Timothy Cormier, Boston Univ. (United States)
Alexis Sauer-Budge, Boston Univ. (United States)
Rachita Chaudhury, Boston Univ. (United States)
Vivian E. Pera, Boston Univ. (United States)
Raeef Istfan, Boston Univ. (United States)
David A. Chargin, Boston Univ. (United States)
Samuel Brookfield, Boston Univ. (United States)
Naomi Yu Ko, Boston Medical Ctr. (United States)
Darren M. Roblyer, Boston Univ. (United States)

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