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Journal of Biomedical Optics • Open Access

Review of optical breast imaging and spectroscopy
Author(s): Dirk Grosenick; Herbert Rinneberg; Rinaldo Cubeddu; Paola Taroni

Paper Abstract

Diffuse optical imaging and spectroscopy of the female breast is an area of active research. We review the present status of this field and discuss the broad range of methodologies and applications. Starting with a brief overview on breast physiology, the remodeling of vasculature and extracellular matrix caused by solid tumors is highlighted that is relevant for contrast in optical imaging. Then, the various instrumental techniques and the related methods of data analysis and image generation are described and compared including multimodality instrumentation, fluorescence mammography, broadband spectroscopy, and diffuse correlation spectroscopy. We review the clinical results on functional properties of malignant and benign breast lesions compared to host tissue and discuss the various methods to improve contrast between healthy and diseased tissue, such as enhanced spectroscopic information, dynamic variations of functional properties, pharmacokinetics of extrinsic contrast agents, including the enhanced permeability and retention effect. We discuss research on monitoring neoadjuvant chemotherapy and on breast cancer risk assessment as potential clinical applications of optical breast imaging and spectroscopy. Moreover, we consider new experimental approaches, such as photoacoustic imaging and long-wavelength tissue spectroscopy.

Paper Details

Date Published: 11 July 2016
PDF: 27 pages
J. Biomed. Opt. 21(9) 091311 doi: 10.1117/1.JBO.21.9.091311
Published in: Journal of Biomedical Optics Volume 21, Issue 9
Show Author Affiliations
Dirk Grosenick, Physikalisch-Technische Bundesanstalt (Germany)
Herbert Rinneberg, Physikalisch-Technische Bundesanstalt (Germany)
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Paola Taroni, Politecnico di Milano (Italy)

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