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Journal of Biomedical Optics • Open Access

From Jöbsis to the present day: a review of clinical near-infrared spectroscopy measurements of cerebral cytochrome-c-oxidase
Author(s): Gemma Bale; Clare E. Elwell; Ilias Tachtsidis

Paper Abstract

Near-infrared spectroscopy (NIRS) measurements of cytochrome-c-oxidase (CCO) have the potential to yield crucial information about cerebral metabolism at the patient bedside. Developments in instrumentation and the analytical methods used to resolve changes in CCO have led to many clinical applications of the measurement since its first demonstration in 1977 by Jöbsis. There is a substantial literature of work on measures of CCO in animal and in vitro studies; however, this review focuses on translational studies. Almost 40 years from the advent of the first measurement of CCO using NIRS, this signal continues to hold significant interest in our understanding of the human brain in health and disease. We discuss methodologies for obtaining NIRS measurements of CCO in the clinic and review studies in neonates and adults.

Paper Details

Date Published: 11 May 2016
PDF: 18 pages
J. Biomed. Opt. 21(9) 091307 doi: 10.1117/1.JBO.21.9.091307
Published in: Journal of Biomedical Optics Volume 21, Issue 9
Show Author Affiliations
Gemma Bale, Univ. College London (United Kingdom)
Clare E. Elwell, Univ. College London (United Kingdom)
Ilias Tachtsidis, Univ. College London (United Kingdom)

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