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Journal of Biomedical Optics • Open Access

Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy
Author(s): Shinsuke Nirengi; Naohiko Inoue; Hitoshi Sato; Toshiyuki Homma; Mami Matsushita; Toshimitsu Kameya; Hiroki Sugie; Takeshi Yoneshiro; Kokoro Tsuzaki; Masayuki Saito; Naoki Sakane; Yuko Kurosawa; Takafumi Hamaoka

Paper Abstract

F18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is widely used as a standard method for evaluating human brown adipose tissue (BAT), a recognized therapeutic target of obesity. However, a longitudinal BAT study using FDG-PET/CT is lacking owing to limitations of the method. Near-infrared time-resolved spectroscopy (NIRTRS) is a technique for evaluating human BAT density noninvasively. This study aimed to test whether NIRTRS could detect changes in BAT density during or after long-term intervention. First, using FDG-PET/CT, we confirmed a significant increase (+48.8%, P<0.05) in BAT activity in the supraclavicular region after 6-week treatment with thermogenic capsaicin analogs, capsinoids. Next, 20 volunteers were administered either capsinoids or placebo daily for 8 weeks in a double-blind design, and BAT density was measured using NIRTRS every 2 weeks during the 8-week treatment period and an 8-week period after stopping treatment. Consistent with FDG-PET/CT results, NIRTRS successfully detected an increase in BAT density during the 8-week treatment (+46.4%, P<0.05), and a decrease in the 8-week follow-up period (−12.5%, P=0.07), only in the capsinoid-treated, but not the placebo, group. Thus, NIRTRS can be applied for quantitative assessment of BAT in longitudinal intervention studies in humans.

Paper Details

Date Published: 2 May 2016
PDF: 7 pages
J. Biomed. Opt. 21(9) 091305 doi: 10.1117/1.JBO.21.9.091305
Published in: Journal of Biomedical Optics Volume 21, Issue 9
Show Author Affiliations
Shinsuke Nirengi, National Hospital Organization Kyoto Medical Ctr. (Japan)
Ritsumeikan Univ. (Japan)
Naohiko Inoue, Ajinomoto Co., Inc. (Japan)
Hitoshi Sato, Ajinomoto Co., Inc. (Japan)
Toshiyuki Homma, Daito Bunka Univ. (Japan)
Mami Matsushita, Tenshi College (Japan)
Toshimitsu Kameya, LSI Sapporo Clinic (Japan)
Hiroki Sugie, LSI Sapporo Clinic (Japan)
Takeshi Yoneshiro, Hokkaido Univ. (Japan)
Kokoro Tsuzaki, National Hospital Organization Kyoto Medical Ctr. (Japan)
Masayuki Saito, Hokkaido Univ. (Japan)
Naoki Sakane, National Hospital Organization Kyoto Medical Ctr. (Japan)
Yuko Kurosawa, Tokyo Medical Univ. (Japan)
Takafumi Hamaoka, Tokyo Medical Univ. (Japan)

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