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Journal of Biomedical Optics

Quantifying tissue viscoelasticity using optical coherence elastography and the Rayleigh wave model
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Paper Abstract

This study demonstrates the feasibility of using the Rayleigh wave model (RWM) in combination with optical coherence elastography (OCE) technique to assess the viscoelasticity of soft tissues. Dispersion curves calculated from the spectral decomposition of OCE-measured air-pulse induced elastic waves were used to quantify the viscoelasticity of samples using the RWM. Validation studies were first conducted on 10% gelatin phantoms with different concentrations of oil. The results showed that the oil increased the viscosity of the gelatin phantom samples. This method was then used to quantify the viscoelasticity of chicken liver. The Young’s modulus of the chicken liver tissues was estimated as E=2.04±0.88  kPa with a shear viscosity η=1.20±0.13  Pa s. The analytical solution of the RWM correlated very well with the OCE-measured phased velocities (R2=0.96±0.04). The results show that the combination of the RWM and OCE is a promising method for noninvasively quantifying the biomechanical properties of soft tissues and may be a useful tool for detecting disease.

Paper Details

Date Published: 20 September 2016
PDF: 4 pages
J. Biomed. Opt. 21(9) 090504 doi: 10.1117/1.JBO.21.9.090504
Published in: Journal of Biomedical Optics Volume 21, Issue 9
Show Author Affiliations
Zhaolong Han, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Salavat R. Aglyamov, The Univ. of Texas at Austin (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Achuth Nair, Univ. of Houston (United States)
Raksha Raghunathan, Univ. of Houston (United States)
Chen Wu, Univ. of Houston (United States)
Jiasong Li, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)
National Research Tomsk State Univ. (Russian Federation)
Baylor College of Medicine (United States)

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