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Journal of Biomedical Optics

Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization
Author(s): Md. Jashim Uddin; Chauca E. Moore; Brenda C. Crews; Cristina K. Daniel; Kebreab Ghebreselasie; J. Oliver McIntyre; Lawrence J. Marnett; Ashwath Jayagopal
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Paper Abstract

Ocular angiogenesis is a blinding complication of age-related macular degeneration and other retinal vascular diseases. Clinical imaging approaches to detect inflammation prior to the onset of neovascularization in these diseases may enable early detection and timely therapeutic intervention. We demonstrate the feasibility of a previously developed cyclooxygenase-2 (COX-2) targeted molecular imaging probe, fluorocoxib A, for imaging retinal inflammation in a mouse model of laser-induced choroidal neovascularization. This imaging probe exhibited focal accumulation within laser-induced neovascular lesions, with minimal detection in proximal healthy tissue. The selectivity of the probe for COX-2 was validated

Paper Details

Date Published: 14 September 2016
PDF: 4 pages
J. Biomed. Opt. 21(9) 090503 doi: 10.1117/1.JBO.21.9.090503
Published in: Journal of Biomedical Optics Volume 21, Issue 9
Show Author Affiliations
Md. Jashim Uddin, Vanderbilt Univ. School of Medicine (United States)
Chauca E. Moore, Vanderbilt Univ. School of Medicine (United States)
Brenda C. Crews, Vanderbilt Univ. School of Medicine (United States)
Cristina K. Daniel, Vanderbilt Univ. School of Medicine (United States)
Kebreab Ghebreselasie, Vanderbilt Univ. School of Medicine (United States)
J. Oliver McIntyre, Vanderbilt Univ. School of Medicine (United States)
Lawrence J. Marnett, Vanderbilt Univ. School of Medicine (United States)
Ashwath Jayagopal, Vanderbilt Univ. School of Medicine (United States)
Pharma Research and Early Development (Switzerland)


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