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Journal of Biomedical Optics

Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging
Author(s): Ivan Olefir; Elena Merčep; Neal C. Burton; Saak V. Ovsepian; Vasilis Ntziachristos
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Paper Abstract

Expanding usage of small animal models in biomedical research necessitates development of technologies for structural, functional, or molecular imaging that can be readily integrated in the biological laboratory. Herein, we consider dual multispectral optoacoustic (OA) and ultrasound tomography based on curved ultrasound detector arrays and describe the performance achieved for hybrid morphological and physiological brain imaging of mice <italic<in vivo</italic<. We showcase coregistered hemodynamic parameters resolved by OA tomography under baseline conditions and during alterations of blood oxygen saturation. As an internal reference, we provide imaging of abdominal organs. We illustrate the performance advantages of hybrid curved detector ultrasound and OA tomography and discuss immediate and long-term implications of our findings in the context of animal and human studies.

Paper Details

Date Published: 12 August 2016
PDF: 10 pages
J. Biomed. Opt. 21(8) 086005 doi: 10.1117/1.JBO.21.8.086005
Published in: Journal of Biomedical Optics Volume 21, Issue 8
Show Author Affiliations
Ivan Olefir, Helmholtz Zentrum München GmbH (Germany)
Technische Univ. München (Germany)
Elena Merčep, Helmholtz Zentrum München (Germany)
Technische Univ. München (Germany)
iThera Medical GmbH (Germany)
Neal C. Burton, iThera Medical GmbH (Germany)
Saak V. Ovsepian, Helmholtz Zentrum München GmbH (Germany)
Technische Univ. München (Germany)
Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany)
Technische Univ. München (Germany)


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