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Journal of Biomedical Optics • new

Enhanced <italic<in vivo</italic< visualization of the microcirculation by topical application of fructose solution confirmed with correlation mapping optical coherence tomography
Author(s): Joey Enfield; James McGrath; Susan M. Daly; Martin J. Leahy
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Paper Abstract

Changes within the microcirculation can provide an early indication of the onset of a plethora of ailments. Various techniques have thus been developed that enable the study of microcirculatory irregularities. Correlation mapping optical coherence tomography (cmOCT) is a recently proposed technique, which enables mapping of vasculature networks at the capillary level in a noninvasive and noncontact manner. This technique is an extension of conventional optical coherence tomography (OCT) and is therefore likewise limited in the penetration depth of ballistic photons in biological media. Optical clearing has previously been demonstrated to enhance the penetration depth and the imaging capabilities of OCT. In order to enhance the achievable maximum imaging depth, we propose the use of optical clearing in conjunction with the cmOCT technique. We demonstrate <italic<in vivo</italic< a 13% increase in OCT penetration depth by topical application of a high-concentration fructose solution, thereby enabling the visualization of vessel features at deeper depths within the tissue.

Paper Details

Date Published: 17 June 2016
PDF: 7 pages
J. Biomed. Opt. 21(8) 081212 doi: 10.1117/1.JBO.21.8.081212
Published in: Journal of Biomedical Optics Volume 21, Issue 8
Show Author Affiliations
Joey Enfield, Tissue Optics and Microcirculation Imaging Facility (Ireland)
James McGrath, National Univ. of Ireland, Galway (Ireland)
Susan M. Daly, Tissue Optics and Microcirculation Imaging Facility (Ireland)
Martin J. Leahy, Tissue Optics and Microcirculation Imaging Facility (Ireland)
National Univ. of Ireland, Galway (Ireland)


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