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Journal of Biomedical Optics • new

Study of optical clearing in polarization measurements by Monte Carlo simulations with anisotropic tissue-mimicking models
Author(s): Dongsheng Chen; Nan Zeng; Yunfei Wang; Honghui He; Valery V. Tuchin; Hui Ma
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Paper Abstract

We conducted Monte Carlo simulations based on anisotropic sclera-mimicking models to examine the polarization features in Mueller matrix polar decomposition (MMPD) parameters during the refractive index matching process, which is one of the major mechanisms of optical clearing. In a preliminary attempt, by changing the parameters of the models, wavelengths, and detection geometries, we demonstrate how the depolarization coefficient and retardance vary during the refractive index matching process and explain the polarization features using the average value and standard deviation of scattering numbers of the detected photons. We also study the depth-resolved polarization features during the gradual progression of the refractive index matching process. The results above indicate that the refractive index matching process increases the depth of polarization measurements and may lead to higher contrast between tissues of different anisotropies in deeper layers. MMPD-derived polarization parameters can characterize the refractive index matching process qualitatively.

Paper Details

Date Published: 31 May 2016
PDF: 9 pages
J. Biomed. Opt. 21(8) 081209 doi: 10.1117/1.JBO.21.8.081209
Published in: Journal of Biomedical Optics Volume 21, Issue 8
Show Author Affiliations
Dongsheng Chen, Graduate School at Shenzhen, Tsinghua Univ. (China)
Nan Zeng, Graduate School at Shenzhen, Tsinghua Univ. (China)
Yunfei Wang, Graduate School at Shenzhen, Tsinghua Univ. (China)
Honghui He, Graduate School at Shenzhen, Tsinghua Univ. (China)
Valery V. Tuchin, Saratov State Univ. (Russia)
Tomsk State Univ. (Russia)
Institute of Precision Mechanics and Control of RAS (Russia)
Hui Ma, Graduate School at Shenzhen, Tsinghua Univ. (China)


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