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Journal of Biomedical Optics • Open Access

Skin optical clearing potential of disaccharides
Author(s): Wei Feng; Rui Shi; Ning Ma; Daria K. Tuchina; Valery V. Tuchin; Dan Zhu

Paper Abstract

Skin optical clearing can significantly enhance the ability of biomedical optical imaging. Some alcohols and sugars have been selected to be optical clearing agents (OCAs). In this work, we paid attention to the optical clearing potential of disaccharides. Sucrose and maltose were chosen as typical disaccharides to compare with fructose, an excellent monosaccharide-OCA, by using molecular dynamics simulation and an <italic<ex vivo</italic< experiment. The experimental results indicated that the optical clearing efficacy of skin increases linearly with the concentration for each OCA. Both the theoretical predication and experimental results revealed that the two disaccharides exerted a better optical clearing potential than fructose at the same concentration, and sucrose is optimal. Since maltose has an extremely low saturation concentration, the other two OCAs with saturation concentrations were treated topically on rat skin <italic<in vivo</italic<, and optical coherence tomography imaging was applied to monitor the optical clearing process. The results demonstrated that sucrose could cause a more significant increase in imaging depth and signal intensity than fructose.

Paper Details

Date Published: 25 April 2016
PDF: 8 pages
J. Biomed. Opt. 21(8) 081207 doi: 10.1117/1.JBO.21.8.081207
Published in: Journal of Biomedical Optics Volume 21, Issue 8
Show Author Affiliations
Wei Feng, Britton Chance Ctr. for Biomedical Photonics (China)
Huazhong Univ. of Science and Technology (China)
Rui Shi, Britton Chance Ctr. for Biomedical Photonics (China)
Huazhong Univ. of Science and Technology (China)
Ning Ma, Huazhong Univ. of Science and Technology (China)
Britton Chance Ctr. for Biomedical Photonics (China)
Daria K. Tuchina, Saratov State Univ. (Russian Federation)
Valery V. Tuchin, Saratov State Univ. (Russian Federation)
Institute of Precise Mechanics and Control (Russian Federation)
Tomsk State Univ. (Russian Federation)
Dan Zhu, Huazhong Univ. of Science and Technology (China)
Britton Chance Ctr. for Biomedical Photonics (China)


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