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Journal of Biomedical Optics

Focused ultrasound-mediated sonochemical internalization: an alternative to light-based therapies
Author(s): Jonathan Gonzales; Rohit K. Nair; Steen J. Madsen; Tatiana Krasieva; Henry Hirschberg
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Paper Abstract

Activation of sonosensitizers via focused ultrasound (FUS), i.e., sonodynamic therapy has been proposed as an extension to light-activated photodynamic therapy for the treatment of brain as well as other tumors. The use of FUS, as opposed to light, allows treatment to tumor sites buried deep within tissues as well as through the intact skull. We have examined ultrasonic activation of sonosensitizers together with the anticancer agent bleomycin (BLM), i.e., sonochemical internalization (SCI). SCI is a technique that utilizes FUS for the enhanced delivery of endo-lysosomal trapped macromolecules into the cell cytoplasm in a similar manner to light-based photochemical internalization. The released agent can, therefore, exert its full biological activity, in contrast to being degraded by lysosomal hydrolases. Our results indicate that, compared to drug or FUS treatment alone, FUS activation of the sonosensitizer AlPcS2a together with BLM significantly inhibits the ability of treated glioma cells to grow as three-dimensional tumor spheroids in vitro.

Paper Details

Date Published: 21 July 2016
PDF: 6 pages
J. Biomed. Opt. 21(7) 078002 doi: 10.1117/1.JBO.21.7.078002
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Jonathan Gonzales, Beckman Laser Institute and Medical Clinic (United States)
Rohit K. Nair, Beckman Laser Institute and Medical Clinic (United States)
Steen J. Madsen, Univ. of Nevada, Las Vegas (United States)
Tatiana Krasieva, Beckman Laser Institute and Medical Clinic (United States)
Henry Hirschberg, Beckman Laser Institute and Medical Clinic (United States)
Univ. of Nevada, Las Vegas (United States)


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