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Journal of Biomedical Optics

Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration
Author(s): Nicolai Brill; Mathias Wirtz; Dorit Merhof; Markus Tingart; Holger Jahr; Daniel Truhn; Robert Schmitt; Sven Nebelung
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Paper Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) is a light-based, high-resolution, real-time, noninvasive, and nondestructive imaging modality yielding quasimicroscopic cross-sectional images of cartilage. As yet, comprehensive parameterization and quantification of birefringence and tissue properties have not been performed on human cartilage. PS-OCT and algorithm-based image analysis were used to objectively grade human cartilage degeneration in terms of surface irregularity, tissue homogeneity, signal attenuation, as well as birefringence coefficient and band width, height, depth, and number. Degeneration-dependent changes were noted for the former three parameters exclusively, thereby questioning the diagnostic value of PS-OCT in the assessment of human cartilage degeneration.

Paper Details

Date Published: 22 July 2016
PDF: 12 pages
J. Biomed. Opt. 21(7) 076013 doi: 10.1117/1.JBO.21.7.076013
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Nicolai Brill, Fraunhofer-Institut für Produktionstechnologie IPT (Germany)
Mathias Wirtz, Fraunhofer-Institut für Produktionstechnologie IPT (Germany)
Dorit Merhof, RWTH Aachen Univ. (Germany)
Markus Tingart, Uniklinik RWTH Aachen (Germany)
Holger Jahr, Uniklinik RWTH Aachen (Germany)
Daniel Truhn, Uniklinik RWTH Aachen (Germany)
Robert Schmitt, Fraunhofer-Institut für Produktionstechnologie IPT (Germany)
RWTH Aachen Univ. (Germany)
Sven Nebelung, Uniklinik RWTH Aachen (Germany)

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