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Journal of Biomedical Optics • Open Access

Quantification of choroidal neovascularization vessel length using optical coherence tomography angiography
Author(s): Simon S. Gao; Li Liu; Steven T. Bailey; Christina J. Flaxel; David Huang; Dengwang Li; Yali Jia

Paper Abstract

Quantification of choroidal neovascularization (CNV) as visualized by optical coherence tomography angiography (OCTA) may have importance clinically when diagnosing or tracking disease. Here, we present an automated algorithm to quantify the vessel skeleton of CNV as vessel length. Initial segmentation of the CNV on en face angiograms was achieved using saliency-based detection and thresholding. A level set method was then used to refine vessel edges. Finally, a skeleton algorithm was applied to identify vessel centerlines. The algorithm was tested on nine OCTA scans from participants with CNV and comparisons of the algorithm’s output to manual delineation showed good agreement.

Paper Details

Date Published: 19 July 2016
PDF: 8 pages
J. Biomed. Opt. 21(7) 076010 doi: 10.1117/1.JBO.21.7.076010
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Simon S. Gao, Casey Eye Institute (United States)
Li Liu, Casey Eye Institute (United States)
Southeast Univ. (China)
Steven T. Bailey, Casey Eye Institute (United States)
Christina J. Flaxel, Casey Eye Institute (United States)
David Huang, Casey Eye Institute (United States)
Dengwang Li, Shandong Normal Univ. (China)
Yali Jia, Casey Eye Institute (United States)

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