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Journal of Biomedical Optics

High-speed, sparse-sampling three-dimensional photoacoustic computed tomography <italic<in vivo</italic< based on principal component analysis
Author(s): Jing Meng; Zibo Jiang; Lihong V. Wang; Jongin Park; Chulhong Kim; Mingjian Sun; Yuanke Zhang; Liang Song
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Paper Abstract

Photoacoustic computed tomography (PACT) has emerged as a unique and promising technology for multiscale biomedical imaging. To fully realize its potential for various preclinical and clinical applications, development of systems with high imaging speed, reasonable cost, and manageable data flow are needed. Sparse-sampling PACT with advanced reconstruction algorithms, such as compressed-sensing reconstruction, has shown potential as a solution to this challenge. However, most such algorithms require iterative reconstruction and thus intense computation, which may lead to excessively long image reconstruction times. Here, we developed a principal component analysis (PCA)-based PACT (PCA-PACT) that can rapidly reconstruct high-quality, three-dimensional (3-D) PACT images with sparsely sampled data without requiring an iterative process. In vivo images of the vasculature of a human hand were obtained, thus validating the PCA-PACT method. The results showed that, compared with the back-projection (BP) method, PCA-PACT required ∼50% fewer measurements and ∼40% less time for image reconstruction, and the imaging quality was almost the same as that for BP with full sampling. In addition, compared with compressed sensing-based PACT, PCA-PACT had approximately sevenfold faster imaging speed with higher imaging accuracy. This work suggests a promising approach for low-cost, 3-D, rapid PACT for various biomedical applications.

Paper Details

Date Published: 18 July 2016
PDF: 8 pages
J. Biomed. Opt. 21(7) 076007 doi: 10.1117/1.JBO.21.7.076007
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Jing Meng, Qufu Normal Univ. (China)
Zibo Jiang, Qufu Normal Univ. (China)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Jongin Park, Pohang Univ. of Science and Technology (Republic of Korea)
Chulhong Kim, Pohang Univ. of Science and Technology (Republic of Korea)
Mingjian Sun, Harbin Institute of Technology (China)
Yuanke Zhang, Qufu Normal Univ. (China)
Liang Song, Shenzhen Institute of Advanced Technology (China)


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