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Journal of Biomedical Optics

Continuous-terahertz-wave molecular imaging system for biomedical applications
Author(s): Rui Zhang; Liangliang Zhang; Tong Wu; Ruixue Wang; Shasha Zuo; Dong Wu; Cunlin Zhang; Jue Zhang; Jing Fang
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Paper Abstract

Molecular imaging techniques are becoming increasingly important in biomedical research and potentially in clinical practice. We present a continuous-terahertz (THz)-wave molecular imaging system for biomedical applications, in which an infrared (IR) laser is integrated into a 0.2-THz reflection-mode continuous-THz-wave imaging system to induce surface plasmon polaritons on the nanoparticles and further improve the intensity of the reflected signal from the water around the nanoparticles. A strong and rapid increment of the reflected THz signal in the nanoparticle solution upon the IR laser irradiation is demonstrated, using either gold or silver nanoparticles. This low-cost, simple, and stable continuous-THz-wave molecular imaging system is suitable for miniaturization and practical imaging applications; in particular, it shows great promise for cancer diagnosis and nanoparticle drug-delivery monitoring.

Paper Details

Date Published: 12 July 2016
PDF: 5 pages
J. Biomed. Opt. 21(7) 076006 doi: 10.1117/1.JBO.21.7.076006
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Rui Zhang, Peking Univ. (China)
Liangliang Zhang, Capital Normal Univ. (China)
Tong Wu, Capital Normal Univ. (China)
Ruixue Wang, Peking Univ. (China)
Shasha Zuo, Peking Univ. (China)
Dong Wu, Peking Univ. (China)
Cunlin Zhang, Capital Normal Univ. (China)
Jue Zhang, Peking Univ. (China)
Jing Fang, Peking Univ. (China)

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