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Journal of Biomedical Optics

Characterization of lipid-rich plaques using spectroscopic optical coherence tomography
Author(s): Hyeong Soo Nam; Joon Woo Song; Sun-Joo Jang; Jae Joong Lee; Wang-Yuhl Oh; Jin Won Kim; Hongki Yoo
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Paper Abstract

Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries <italic<in vivo</italic<. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated <italic<in vivo</italic< using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.

Paper Details

Date Published: 8 July 2016
PDF: 9 pages
J. Biomed. Opt. 21(7) 075004 doi: 10.1117/1.JBO.21.7.075004
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Hyeong Soo Nam, Hanyang Univ. (Korea, Republic of)
Joon Woo Song, Korea Univ. Medical Ctr. (Republic of Korea)
Sun-Joo Jang, Korea Advanced Institute of Science and Technology (Republic of Korea)
Jae Joong Lee, Korea Univ. (Republic of Korea)
Wang-Yuhl Oh, KAIST (Republic of Korea)
Jin Won Kim, Korea Univ. (Republic of Korea)
Hongki Yoo, Hanyang Univ. (Republic of Korea)

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