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Journal of Biomedical Optics • Open Access

Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging
Author(s): Anaïs Leproux; You Me Kim; Jun Won Min; Christine E. McLaren; Wen-Pin Chen; Thomas D. O'Sullivan; Seung-ha Lee; Phil-Sang Chung; Bruce J. Tromberg

Paper Abstract

Young patients with dense breasts have a relatively low-positive biopsy rate for breast cancer (∼1 in 7). South Korean women have higher breast density than Westerners. We investigated the benefit of using a functional and metabolic imaging technique, diffuse optical spectroscopic imaging (DOSI), to help the standard of care imaging tools to distinguish benign from malignant lesions in premenopausal Korean women. DOSI uses near-infrared light to measure breast tissue composition by quantifying tissue concentrations of water (ctH2O), bulk lipid (ctLipid), deoxygenated (ctHHb), and oxygenated (ctHbO2) hemoglobin. DOSI spectral signatures specific to abnormal tissue and absent in healthy tissue were also used to form a malignancy index. This study included 19 premenopausal subjects (average age 41±9), corresponding to 11 benign and 10 malignant lesions. Elevated lesion to normal ratio of ctH2O, ctHHb, ctHbO2, total hemoglobin (THb=ctHHb+ctHbO2), and tissue optical index (ctHHb×ctH2O/ctLipid) were observed in the malignant lesions compared to the benign lesions (p<0.02). THb and malignancy index were the two best single predictors of malignancy, with >90% sensitivity and specificity. Malignant lesions showed significantly higher metabolism and perfusion than benign lesions. DOSI spectral features showed high discriminatory power for distinguishing malignant and benign lesions in dense breasts of the Korean population.

Paper Details

Date Published: 20 July 2016
PDF: 10 pages
J. Biomed. Opt. 21(7) 074001 doi: 10.1117/1.JBO.21.7.074001
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Anaïs Leproux, Beckman Laser Institute and Medical Clinic (United States)
You Me Kim, Dankook Univ. (Korea, Republic of)
Jun Won Min, Dankook Univ. (Korea, Republic of)
Christine E. McLaren, Univ. of California, Irvine (United States)
Wen-Pin Chen, Univ. of California, Irvine (United States)
Thomas D. O'Sullivan, Univ. of California, Irvine (United States)
Seung-ha Lee, Dankook Univ. (Korea, Republic of)
Phil-Sang Chung, Dankook Univ. Hospital (Korea, Republic of)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)

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