Share Email Print
cover

Journal of Biomedical Optics • Open Access • new

Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues
Author(s): Ye Wang; Honghui He; Jintao Chang; Chao He; Shaoxiong Liu; Migao Li; Nan Zeng; Jian Wu; Hui Ma

Paper Abstract

Today the increasing cancer incidence rate is becoming one of the biggest threats to human health. Among all types of cancers, liver cancer ranks in the top five in both frequency and mortality rate all over the world. During the development of liver cancer, fibrosis often evolves as part of a healing process in response to liver damage, resulting in cirrhosis of liver tissues. In a previous study, we applied the Mueller matrix microscope to pathological liver tissue samples and found that both the Mueller matrix polar decomposition (MMPD) and Mueller matrix transformation (MMT) parameters are closely related to the fibrous microstructures. In this paper, we take this one step further to quantitatively facilitate the fibrosis detections and scorings of pathological liver tissue samples in different stages from cirrhosis to cancer using the Mueller matrix microscope. The experimental results of MMPD and MMT parameters for the fibrotic liver tissue samples in different stages are measured and analyzed. We also conduct Monte Carlo simulations based on the sphere birefringence model to examine in detail the influence of structural changes in different fibrosis stages on the imaging parameters. Both the experimental and simulated results indicate that the polarized light microscope and transformed Mueller matrix parameters can provide additional quantitative information helpful for fibrosis detections and scorings of liver cirrhosis and cancers. Therefore, the polarized light microscope and transformed Mueller matrix parameters have a good application prospect in liver cancer diagnosis.

Paper Details

Date Published: 18 April 2016
PDF: 9 pages
J. Biomed. Opt. 21(7) 071112 doi: 10.1117/1.JBO.21.7.071112
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Ye Wang, Graduate School at Shenzhen, Tsinghua Univ. (China)
Honghui He, Graduate School at Shenzhen, Tsinghua Univ. (China)
Jintao Chang, Graduate School at Shenzhen, Tsinghua Univ. (China)
Chao He, Graduate School at Shenzhen, Tsinghua Univ. (China)
Shaoxiong Liu, Huazhong Univ. of Science and Technology (China)
Migao Li, Guangzhou Liss Optical Instrument Co., Ltd. (China)
Nan Zeng, Graduate School at Shenzhen, Tsinghua Univ. (China)
Jian Wu, Graduate School at Shenzhen, Tsinghua Univ. (China)
Hui Ma, Graduate School at Shenzhen, Tsinghua Univ. (China)


© SPIE. Terms of Use
Back to Top