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Journal of Biomedical Optics • Open Access

Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue
Author(s): Joseph Chue-Sang; Yuqiang Bai; Susan Stoff; David Straton; Sharan D. Ramaswamy; Jessica C. Ramella-Roman

Paper Abstract

Mueller matrix polarimetry and polarization-sensitive optical coherence tomography (PS-OCT) are two emerging techniques utilized in the assessment of tissue anisotropy. While PS-OCT can provide cross-sectional images of local tissue birefringence through its polarimetric sensitivity, Mueller matrix polarimetry can be used to measure bulk polarimetric properties such as depolarization, diattenuation, and retardance. To this day true quantification of PS-OCT data can be elusive, partly due to the reliance on inverse models for the characterization of tissue birefringence and the influence of instrumentation noise. Similarly for Mueller matrix polarimetry, calculation of retardance or depolarization may be influenced by tissue heterogeneities that could be monitored with PS-OCT. Here, we propose an instrument that combines Mueller matrix polarimetry and PS-OCT. Through the co-registration of the two systems, we aim at achieving a better understanding of both modalities.

Paper Details

Date Published: 1 March 2016
PDF: 9 pages
J. Biomed. Opt. 21(7) 071109 doi: 10.1117/1.JBO.21.7.071109
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Joseph Chue-Sang, Florida International Univ. (United States)
Yuqiang Bai, Florida International Univ. (United States)
Susan Stoff, Florida International Univ. (United States)
David Straton, Florida International Univ. (United States)
Sharan D. Ramaswamy, Florida International Univ. (United States)
Jessica C. Ramella-Roman, Florida International Univ. (United States)

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