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Journal of Biomedical Optics • Open Access

Optical fiber-based full Mueller polarimeter for endoscopic imaging using a two-wavelength simultaneous measurement method
Author(s): Jérémy Vizet; Sandeep Manhas; Jacqueline Tran; Pierre Validire; Abdelali Benali; Enric Garcia-Caurel; Angelo Pierangelo; Antonello De Martino; Dominique Pagnoux

Paper Abstract

This paper reports a technique based on spectrally differential measurement for determining the full Mueller matrix of a biological sample through an optical fiber. In this technique, two close wavelengths were used simultaneously, one for characterizing the fiber and the other for characterizing the assembly of fiber and sample. The characteristics of the fiber measured at one wavelength were used to decouple its contribution from the measurement on the assembly of fiber and sample and then to extract sample Mueller matrix at the second wavelength. The proof of concept was experimentally validated by measuring polarimetric parameters of various calibrated optical components through the optical fiber. Then, polarimetric images of histological cuts of human colon tissues were measured, and retardance, diattenuation, and orientation of the main axes of fibrillar regions were displayed. Finally, these images were successfully compared with images obtained by a free space Mueller microscope. As the reported method does not use any moving component, it offers attractive integration possibilities with an endoscopic probe.

Paper Details

Date Published: 5 February 2016
PDF: 8 pages
J. Biomed. Opt. 21(7) 071106 doi: 10.1117/1.JBO.21.7.071106
Published in: Journal of Biomedical Optics Volume 21, Issue 7
Show Author Affiliations
Jérémy Vizet, Univ. de Limoges (France)
Sandeep Manhas, Univ. de Limoges (France)
Ecole Polytechnique (France)
Jacqueline Tran, Ecole Polytechnique (France)
Pierre Validire, Institut Mutualiste Montsouris (France)
Abdelali Benali, Institut Mutualiste Montsouris (France)
Enric Garcia-Caurel, Ecole Polytechnique (France)
Angelo Pierangelo, Ecole Polytechnique (France)
Antonello De Martino, Ecole Polytechnique (France)
Dominique Pagnoux, Univ. de Limoges (France)

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