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Journal of Biomedical Optics • Open Access

Low-cost tissue simulating phantoms with adjustable wavelength-dependent scattering properties in the visible and infrared ranges
Author(s): Rolf B. Saager; Alan Quach; Rebecca A. Rowland; Melissa L. Baldado; Anthony J. Durkin

Paper Abstract

We present a method for low-cost fabrication of polydimethylsiloxane (PDMS) tissue simulating phantoms with tunable scattering spectra, spanning visible, and near-infrared regimes. These phantoms use optical polishing agents (aluminum oxide powders) at various grit sizes to approximate in vivo tissue scattering particles across multiple size distributions (range: 17 to 3  μm). This class of tunable scattering phantoms is used to mimic distinct changes in wavelength-dependent scattering properties observed in tissue pathologies such as partial thickness burns. Described by a power-law dependence on wavelength, the scattering magnitude of these phantoms scale linearly with particle concentration over a physiologic range [μ's=(0.5 to 2.0  mm−1)] whereas the scattering spectra, specific to each particle size distribution, correlate to distinct exponential coefficients (range: 0.007 to 0.32). Aluminum oxide powders used in this investigation did not detectably contribute to the absorption properties of these phantoms. The optical properties of these phantoms are verified through inverse adding-doubling methods and the tolerances of this fabrication method are discussed.

Paper Details

Date Published: 13 June 2016
PDF: 6 pages
J. Biomed. Opt. 21(6) 067001 doi: 10.1117/1.JBO.21.6.067001
Published in: Journal of Biomedical Optics Volume 21, Issue 6
Show Author Affiliations
Rolf B. Saager, Univ. of California, Irvine (United States)
Alan Quach, Univ. of California, Irvine (United States)
Rebecca A. Rowland, Univ. of California, Irvine (United States)
Melissa L. Baldado, Univ. of California, Irvine (United States)
Anthony J. Durkin, Univ. of California, Irvine (United States)

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