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Journal of Biomedical Optics • Open Access

Photoacoustic imaging with an acoustic lens detects prostate cancer cells labeled with PSMA-targeting near-infrared dye-conjugates
Author(s): Vikram Dogra; Bhargava Chinni; Shalini Singh; Hans Schmitthenner; Navalgund Rao; John J. Krolewski; Kent L. Nastiuk

Paper Abstract

There is an urgent need for sensitive and specific tools to accurately image early stage, organ-confined human prostate cancers to facilitate active surveillance and reduce unnecessary treatment. Recently, we developed an acoustic lens that enhances the sensitivity of photoacoustic imaging. Here, we report the use of this device in conjunction with two molecular imaging agents that specifically target the prostate-specific membrane antigen (PSMA) expressed on the tumor cell surface of most prostate cancers. We demonstrate successful imaging of phantoms containing cancer cells labeled with either of two different PSMA-targeting agents, the ribonucleic acid aptamer A10-3.2 and a urea-based peptidomimetic inhibitor, each linked to the near-infrared dye IRDye800CW. By specifically targeting cells with these agents linked to a dye chosen for optimal signal, we are able to discriminate prostate cancer cells that express PSMA.

Paper Details

Date Published: 30 June 2016
PDF: 5 pages
J. Biomed. Opt. 21(6) 066019 doi: 10.1117/1.JBO.21.6.066019
Published in: Journal of Biomedical Optics Volume 21, Issue 6
Show Author Affiliations
Vikram Dogra, Univ. of Rochester Medical Ctr. (United States)
Bhargava Chinni, Univ. of Rochester Medical Ctr. (United States)
Shalini Singh, Roswell Park Cancer Institute (United States)
Hans Schmitthenner, Rochester Institute of Technology (United States)
Navalgund Rao, Rochester Institute of Technology (United States)
John J. Krolewski, Univ. of Rochester Medical Ctr. (United States)
Roswell Park Cancer Institute (United States)
Kent L. Nastiuk, Roswell Park Cancer Institute (United States)


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