Share Email Print

Journal of Biomedical Optics • new

Quantitative photoacoustic elastography in humans
Author(s): Pengfei Hai; Yong Zhou; Lei Gong; Lihong V. Wang
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We report quantitative photoacoustic elastography (QPAE) capable of measuring Young’s modulus of biological tissue <italic<in vivo</italic< in humans. By combining conventional PAE with a stress sensor having known stress–strain behavior, QPAE can simultaneously measure strain and stress, from which Young’s modulus is calculated. We first demonstrate the feasibility of QPAE in agar phantoms with different concentrations. The measured Young’s modulus values fit well with both the empirical expectation based on the agar concentrations and those measured in an independent standard compression test. Next, QPAE was applied to quantify the Young’s modulus of skeletal muscle <italic<in vivo</italic< in humans, showing a linear relationship between muscle stiffness and loading. The results demonstrated the capability of QPAE to assess the absolute elasticity of biological tissue noninvasively <italic<in vivo</italic< in humans, indicating its potential for tissue biomechanics studies and clinical applications.

Paper Details

Date Published: 15 June 2016
PDF: 5 pages
J. Biomed. Opt. 21(6) 066011 doi: 10.1117/1.JBO.21.6.066011
Published in: Journal of Biomedical Optics Volume 21, Issue 6
Show Author Affiliations
Pengfei Hai, Washington Univ. in St. Louis (United States)
Yong Zhou, Washington Univ. in St. Louis (United States)
Lei Gong, Washington Univ. in St. Louis (United States)
Univ. of Science and Technology of China (China)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

© SPIE. Terms of Use
Back to Top