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Journal of Biomedical Optics • Open Access

Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography
Author(s): Zhongdi Chu; Jason Lin; Chen Gao; Chen Xin; Qinqin Zhang; Chieh-Li Chen; Luis Roisman; Giovanni Gregori; Philip J. Rosenfeld; Ruikang K. Wang

Paper Abstract

Optical coherence tomography angiography (OCTA) is clinically useful for the qualitative assessment of the macular microvasculature. However, there is a need for comprehensive quantitative tools to help objectively analyze the OCT angiograms. Few studies have reported the use of a single quantitative index to describe vessel density in OCT angiograms. In this study, we introduce a five-index quantitative analysis of OCT angiograms in an attempt to detect and assess vascular abnormalities from multiple perspectives. The indices include vessel area density, vessel skeleton density, vessel diameter index, vessel perimeter index, and vessel complexity index. We show the usefulness of the proposed indices with five illustrative cases. Repeatability is tested on both a healthy case and a stable diseased case, giving interclass coefficients smaller than 0.031. The results demonstrate that our proposed quantitative analysis may be useful as a complement to conventional OCTA for the diagnosis of disease and monitoring of treatment.

Paper Details

Date Published: 10 June 2016
PDF: 13 pages
J. Biomed. Opt. 21(6) 066008 doi: 10.1117/1.JBO.21.6.066008
Published in: Journal of Biomedical Optics Volume 21, Issue 6
Show Author Affiliations
Zhongdi Chu, Univ. of Washington (United States)
Jason Lin, Univ. of Washington (United States)
Chen Gao, Univ. of Washington (United States)
Chen Xin, Univ. of Washington (United States)
Qinqin Zhang, Univ. of Washington (United States)
Chieh-Li Chen, Univ. of Washington (United States)
Luis Roisman, Bascom Palmer Eye Institute (United States)
Giovanni Gregori, Bascom Palmer Eye Institute (United States)
Philip J. Rosenfeld, Bascom Palmer Eye Institute (United States)
Ruikang K. Wang, Univ. of Washington (United States)

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