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Journal of Biomedical Optics • Open Access

Diffuse optical microscopy for quantification of depth-dependent epithelial backscattering in the cervix
Author(s): Nico Bodenschatz; Sylvia F. Lam; Anita Carraro; Jagoda Korbelik; Dianne M. Miller; Jessica N. McAlpine; Marette Lee; Alwin Kienle; Calum E. MacAulay

Paper Abstract

A fiber optic imaging approach is presented using structured illumination for quantification of almost pure epithelial backscattering. We employ multiple spatially modulated projection patterns and camera-based reflectance capture to image depth-dependent epithelial scattering. The potential diagnostic value of our approach is investigated on cervical <italic<ex vivo</italic< tissue specimens. Our study indicates a strong backscattering increase in the upper part of the cervical epithelium caused by dysplastic microstructural changes. Quantization of relative depth-dependent backscattering is confirmed as a potentially useful diagnostic feature for detection of precancerous lesions in cervical squamous epithelium.

Paper Details

Date Published: 1 June 2016
PDF: 9 pages
J. Biomed. Opt. 21(6) 066001 doi: 10.1117/1.JBO.21.6.066001
Published in: Journal of Biomedical Optics Volume 21, Issue 6
Show Author Affiliations
Nico Bodenschatz, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)
British Columbia Cancer Research Centre (Canada)
Sylvia F. Lam, BC Cancer Research Ctr. (Canada)
Anita Carraro, BC Cancer Research Ctr. (Canada)
Jagoda Korbelik, BC Cancer Research Ctr. (Canada)
Dianne M. Miller, The Univ. of British Columbia (Canada)
Jessica N. McAlpine, The Univ. of British Columbia (Canada)
Marette Lee, The Univ. of British Columbia (Canada)
Alwin Kienle, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)
Calum E. MacAulay, BC Cancer Research Ctr. (Canada)


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