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Journal of Biomedical Optics • new

Stimulus-evoked outer segment changes in rod photoreceptors
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Paper Abstract

Rod-dominated transient retinal phototropism (TRP) has been recently observed in freshly isolated mouse and frog retinas. Comparative confocal microscopy and optical coherence tomography revealed that the TRP was predominantly elicited from the rod outer segment (OS). However, the biophysical mechanism of rod OS dynamics is still unknown. Mouse and frog retinal slices, which displayed a cross-section of retinal photoreceptors and other functional layers, were used to test the effect of light stimulation on rod OSs. Time-lapse microscopy revealed stimulus-evoked conformational changes of rod OSs. In the center of the stimulated region, the length of the rod OS shrunk, while in the peripheral region, the rod OS swung toward the center region. Our experimental observation and theoretical analysis suggest that the TRP may reflect unbalanced rod disc-shape changes due to localized visible light stimulation.

Paper Details

Date Published: 23 June 2016
PDF: 8 pages
J. Biomed. Opt. 21(6) 065006 doi: 10.1117/1.JBO.21.6.065006
Published in: Journal of Biomedical Optics Volume 21, Issue 6
Show Author Affiliations
Xiaohui Zhao, Hebei Univ. (China)
Univ. of Illinois at Chicago (United States)
Damber Thapa, Univ. of Illinois at Chicago (United States)
Benquan Wang, Univ. of Illinois at Chicago (United States)
Yiming Lu, Univ. of Illinois at Chicago (United States)
Shaoyan Gai, Univ. of Illinois at Chicago (United States)
Xincheng Yao, Hebei Univ. (China)
Univ. of Illinois at Chicago (United States)

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