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Journal of Biomedical Optics

<italic<In vivo</italic< imaging of melanoma-implanted magnetic nanoparticles using contrast-enhanced magneto-motive optical Doppler tomography
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Paper Abstract

We conducted an initial feasibility study using real-time magneto-motive optical Doppler tomography (MM-ODT) with enhanced contrast to investigate the detection of superparamagnetic iron oxide (SPIO) magnetic nanoparticles implanted into <italic<in vivo</italic< melanoma tissue. The MM-ODT signals were detected owing to the phase shift of the implanted magnetic nanoparticles, which occurred due to the action of an applied magnetic field. An amplifier circuit-based solenoid was utilized for generating high-intensity oscillating magnetic fields. The MM-ODT system was confirmed as an effective <italic<in vivo</italic< imaging method for detecting melanoma tissue, with the performance comparable to those of conventional optical coherence tomography and optical Doppler tomography methods. Moreover, the optimal values of the SPIO nanoparticles concentration and solenoid voltage for obtaining the uppermost Doppler velocity were derived as well. To improve the signal processing speed for real-time imaging, we adopted multithread programming techniques and optimized the signal path. The results suggest that this imaging modality can be used as a powerful tool to identify the intracellular and extracellular SPIO nanoparticles in melanoma tissues <italic<in vivo</italic<.

Paper Details

Date Published: 21 June 2016
PDF: 6 pages
J. Biomed. Opt. 21(6) 064001 doi: 10.1117/1.JBO.21.6.064001
Published in: Journal of Biomedical Optics Volume 21, Issue 6
Show Author Affiliations
Ruchire Eranga Wijesinghe, Kyungpook National Univ. (Republic of Korea)
Kibeom Park, Kyungpook National Univ. (Republic of Korea)
Dong-Hyeon Kim, Kyungpook National Univ. (Republic of Korea)
Mansik Jeon, Kyungpook National Univ. (Republic of Korea)
Jeehyun Kim, Kyungpook National Univ. (Republic of Korea)

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