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Journal of Biomedical Optics • Open Access

Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography
Author(s): Xinwen Yao; Yu Gan; Charles C. Marboe; Christine P. Hendon

Paper Abstract

We present an ultrahigh-resolution spectral domain optical coherence tomography (OCT) system in 800 nm with a low-noise supercontinuum source (SC) optimized for myocardial imaging. The system was demonstrated to have an axial resolution of 2.72  μm with a large imaging depth of 1.78 mm and a 6-dB falloff range of 0.89 mm. The lateral resolution (5.52  μm) was compromised to enhance the image penetration required for myocardial imaging. The noise of the SC source was analyzed extensively and an imaging protocol was proposed for SC-based OCT imaging with appreciable contrast. Three-dimensional datasets were acquired ex vivo on the endocardium side of tissue specimens from different chambers of fresh human and swine hearts. With the increased resolution and contrast, features such as elastic fibers, Purkinje fibers, and collagen fiber bundles were observed. The correlation between the structural information revealed in the OCT images and tissue pathology was discussed as well.

Paper Details

Date Published: 22 March 2016
PDF: 13 pages
J. Biomed. Opt. 21(6) 061006 doi: 10.1117/1.JBO.21.6.061006
Published in: Journal of Biomedical Optics Volume 21, Issue 6
Show Author Affiliations
Xinwen Yao, Columbia Univ. (United States)
Yu Gan, Columbia Univ. (United States)
Charles C. Marboe, Columbia Univ. Medical Ctr. (United States)
Christine P. Hendon, Columbia Univ. (United States)

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