Share Email Print

Journal of Biomedical Optics • Open Access

In vivo photoacoustic tomography of myoglobin oxygen saturation

Paper Abstract

Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO2-Mb). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO2-Mb change in the backbone muscle in vivo.

Paper Details

Date Published: 17 December 2015
PDF: 5 pages
J. Biomed. Opt. 21(6) 061002 doi: 10.1117/1.JBO.21.6.061002
Published in: Journal of Biomedical Optics Volume 21, Issue 6
Show Author Affiliations
Li Lin, Washington Univ. in St. Louis (United States)
Junjie Yao, Washington Univ. in St. Louis (United States)
Lei Li, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

© SPIE. Terms of Use
Back to Top