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Journal of Biomedical Optics • Open Access

<italic<In vivo</italic< isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy

Paper Abstract

Skin is a highly structured tissue, raising concerns as to whether skin pigmentation due to epidermal melanin may confound accurate measurements of underlying hemodynamics. Using both venous and arterial cuff occlusions as a means of inducing differential hemodynamic perturbations, we present analyses of spectra limited to the visible or near-infrared regime, in addition to a layered model approach. The influence of melanin, spanning Fitzpatrick skin types I to V, on underlying estimations of hemodynamics in skin as interpreted by these spectral regions are assessed. The layered model provides minimal cross-talk between melanin and hemodynamics and enables removal of problematic correlations between measured tissue oxygenation estimates and skin phototype.

Paper Details

Date Published: 3 May 2016
PDF: 9 pages
J. Biomed. Opt. 21(5) 057001 doi: 10.1117/1.JBO.21.5.057001
Published in: Journal of Biomedical Optics Volume 21, Issue 5
Show Author Affiliations
Rolf B. Saager, Univ. of California, Irvine (United States)
Ata Sharif, Univ. of California, Irvine (United States)
Kristen M. Kelly, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Anthony J. Durkin, Univ. of California, Irvine (United States)

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