Share Email Print

Journal of Biomedical Optics • Open Access

Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy
Author(s): Changhong Shi; Jason B. Wu; Dongfeng Pan

Paper Abstract

A class of near-infrared fluorescence (NIRF) heptamethine cyanine dyes that are taken up and accumulated specifically in cancer cells without chemical conjugation have recently emerged as promising tools for tumor imaging and targeting. In addition to their fluorescence and nuclear imaging-based tumor-imaging properties, these dyes can be developed as drug carriers to safely deliver chemotherapy drugs to tumors. They can also be used as effective agents for photodynamic therapy with remarkable tumoricidal activity via photodependent cytotoxic activity. The preferential uptake of dyes into cancer but not normal cells is co-operatively mediated by the prevailing activation of a group of organic anion-transporting polypeptides on cancer cell membranes, as well as tumor hypoxia and increased mitochondrial membrane potential in cancer cells. Such mechanistic explorations have greatly advanced the current application and future development of NIRF dyes and their derivatives as anticancer theranostic agents. This review summarizes current knowledge and emerging advances in NIRF dyes, including molecular characterization, photophysical properties, multimodal development and uptake mechanisms, and their growing potential for preclinical and clinical use.

Paper Details

Date Published: 10 May 2016
PDF: 11 pages
J. Biomed. Opt. 21(5) 050901 doi: 10.1117/1.JBO.21.5.050901
Published in: Journal of Biomedical Optics Volume 21, Issue 5
Show Author Affiliations
Changhong Shi, Fourth Military Medical Univ. (China)
Jason B. Wu, Cedars-Sinai Medical Ctr. (United States)
Dongfeng Pan, Univ. of Virginia (United States)

© SPIE. Terms of Use
Back to Top