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Journal of Biomedical Optics

Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery
Author(s): Antonello Enrico Spinelli; Marco Paolo Schiariti; Chiara Maria Grana; Mahila Ferrari; Marta Cremonesi; Federico Boschi
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Paper Abstract

We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of 90Y-DOTATOC the day before neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f/0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery.

Paper Details

Date Published: 9 May 2016
PDF: 4 pages
J. Biomed. Opt. 21(5) 050502 doi: 10.1117/1.JBO.21.5.050502
Published in: Journal of Biomedical Optics Volume 21, Issue 5
Show Author Affiliations
Antonello Enrico Spinelli, Istituto Scientifico San Raffaele (Italy)
Marco Paolo Schiariti, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (Italy)
Chiara Maria Grana, Istituto Europeo di Oncologia (Italy)
Mahila Ferrari, Istituto Europeo di Oncologia (Italy)
Marta Cremonesi, Istituto Europeo di Oncologia (Italy)
Federico Boschi, Univ. degli Studi di Verona (Italy)


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