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Journal of Biomedical Optics

Detection of capecitabine (Xeloda®) on the skin surface after oral administration
Author(s): Mao-Dong Huang; Harald Fuss; Jürgen M. Lademann; Stefan Florek; Alexa Patzelt; Martina C. Meinke; Sora Jung
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Paper Abstract

Palmoplantar erythrodysesthesia (PPE), or hand-foot syndrome, is a cutaneous toxicity under various chemotherapeutics contributing to the most frequent side effects in patients treated with capecitabine (Xeloda®). The pathomechanism of PPE has been unclear. Here, the topical detection of capecitabine in the skin after oral application was shown in 10 patients receiving 2500  mg/m2/day capecitabine. Sweat samples were taken prior to and one week after oral administration of capecitabine. Using high-resolution continuum source absorption spectrometry, the changes in concentrations of fluorine, which is an ingredient of capecitabine, were quantified and statistically analyzed. Here, we show an increase in fluorine concentrations from 40±10  ppb (2±0.5  pM) before capecitabine administration to 27.7±11.8  ppm (14.6±6.5  nM) after application, p<0.001. The results show the secretion of capecitabine on the skin surface after oral administration, indicating a local toxic effect as a possible pathomechanism of PPE.

Paper Details

Date Published: 26 April 2016
PDF: 4 pages
J. Biomed. Opt. 21(4) 047002 doi: 10.1117/1.JBO.21.4.047002
Published in: Journal of Biomedical Optics Volume 21, Issue 4
Show Author Affiliations
Mao-Dong Huang, Leibniz-Institut für Analytische Wissenschaften ISAS e.V. (Germany)
Harald Fuss, HELIOS-Klinikum Berlin-Buch (Germany)
Jürgen M. Lademann, Charité Universitätsmedizin Berlin (Germany)
Stefan Florek, Leibniz-Institut für Analytische Wissenschaften ISAS e.V.. (Germany)
Alexa Patzelt, Charité Universitätsmedizin Berlin (Germany)
Martina C. Meinke, Charité–Universitätsmedizin Berlin (Germany)
Sora Jung, Charité Universitätsmedizin Berlin (Germany)


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