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Journal of Biomedical Optics

Direct reconstruction in CT-analogous pharmacokinetic diffuse fluorescence tomography: two-dimensional simulative and experimental validations
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Paper Abstract

We present a generalized strategy for direct reconstruction in pharmacokinetic diffuse fluorescence tomography (DFT) with CT-analogous scanning mode, which can accomplish one-step reconstruction of the indocyanine-green pharmacokinetic-rate images within <italic<in vivo</italic< small animals by incorporating the compartmental kinetic model into an adaptive extended Kalman filtering scheme and using an instantaneous sampling dataset. This scheme, compared with the established indirect and direct methods, eliminates the interim error of the DFT inversion and relaxes the expensive requirement of the instrument for obtaining highly time-resolved date-sets of complete 360 deg projections. The scheme is validated by two-dimensional simulations for the two-compartment model and pilot phantom experiments for the one-compartment model, suggesting that the proposed method can estimate the compartmental concentrations and the pharmacokinetic-rates simultaneously with a fair quantitative and localization accuracy, and is well suitable for cost-effective and dense-sampling instrumentation based on the highly-sensitive photon counting technique.

Paper Details

Date Published: 19 April 2016
PDF: 10 pages
J. Biomed. Opt. 21(4) 046007 doi: 10.1117/1.JBO.21.4.046007
Published in: Journal of Biomedical Optics Volume 21, Issue 4
Show Author Affiliations
Xin Wang, Tianjin Univ. (China)
Yanqi Zhang, Tianjin Univ. (China)
Limin Zhang, Tianjin Univ. (China)
Jiao Li, Tianjin Univ. (China)
Zhongxing Zhou, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)

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