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Journal of Biomedical Optics

Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies
Author(s): Hassan S. Salehi; Hai Li; Alex Merkulov; Patrick D. Kumavor; Hamed Vavadi; Melinda Sanders; Angela Kueck; Molly A. Brewer; Quing Zhu
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Paper Abstract

Most ovarian cancers are diagnosed at advanced stages due to the lack of efficacious screening techniques. Photoacoustic tomography (PAT) has a potential to image tumor angiogenesis and detect early neovascular changes of the ovary. We have developed a coregistered PAT and ultrasound (US) prototype system for real-time assessment of ovarian masses. Features extracted from PAT and US angular beams, envelopes, and images were input to a logistic classifier and a support vector machine (SVM) classifier to diagnose ovaries as benign or malignant. A total of 25 excised ovaries of 15 patients were studied and the logistic and SVM classifiers achieved sensitivities of 70.4 and 87.7%, and specificities of 95.6 and 97.9%, respectively. Furthermore, the ovaries of two patients were noninvasively imaged using the PAT/US system before surgical excision. By using five significant features and the logistic classifier, 12 out of 14 images (86% sensitivity) from a malignant ovarian mass and all 17 images (100% specificity) from a benign mass were accurately classified; the SVM correctly classified 10 out of 14 malignant images (71% sensitivity) and all 17 benign images (100% specificity). These initial results demonstrate the clinical potential of the PAT/US technique for ovarian cancer diagnosis.

Paper Details

Date Published: 18 April 2016
PDF: 11 pages
J. Biomed. Opt. 21(4) 046006 doi: 10.1117/1.JBO.21.4.046006
Published in: Journal of Biomedical Optics Volume 21, Issue 4
Show Author Affiliations
Hassan S. Salehi, Univ. of Connecticut (United States)
Hai Li, Univ. of Connecticut (United States)
Alex Merkulov, Univ. of Connecticut Health Ctr. (United States)
Patrick D. Kumavor, Univ. of Connecticut (United States)
Hamed Vavadi, Univ. of Connecticut (United States)
Melinda Sanders, Univ. of Connecticut Health Ctr. (United States)
Angela Kueck, Univ. of Connecticut Health Ctr. (United States)
Molly A. Brewer, Univ. of Connecticut Health Ctr. (United States)
Quing Zhu, Univ. of Connecticut (United States)


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