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Journal of Biomedical Optics

Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography
Author(s): Yong Du; Chih-Hao Liu; Ling Lei; Manmohan Singh; Jiasong Li; M. John Hicks; Kirill V. Larin; Chandra Mohan
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Paper Abstract

Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc has a rare morbidity (276 cases per million adults in the United States), but has a 10-year survival rate of 55%. Currently, the modified Rodnan skin score (mRSS) is assessed by palpation on 17 sites on the body. However, the mRSS assessed score is subjective and may be influenced by the experience of the rheumatologists. In addition, the inherent elasticity of skin may bias the mRSS assessment in the early stage of SSc, such as oedematous. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess mechanical contrast in tissues with micrometer spatial resolution. In this work, the OCE technique is applied to assess the mechanical properties of skin in both control and bleomycin (BLM) induced SSc-like disease noninvasively. Young’s modulus of the BLM-SSc skin was found be significantly higher than that of normal skin, in both the in vivo and in vitro studies (p<0.05). Thus, OCE is able to differentiate healthy and fibrotic skin using mechanical contrast. It is a promising new technology for quantifying skin involvement in SSc in a rapid, unbiased, and noninvasive manner.

Paper Details

Date Published: 5 April 2016
PDF: 9 pages
J. Biomed. Opt. 21(4) 046002 doi: 10.1117/1.JBO.21.4.046002
Published in: Journal of Biomedical Optics Volume 21, Issue 4
Show Author Affiliations
Yong Du, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Ling Lei, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Jiasong Li, Univ. of Houston (United States)
M. John Hicks, Baylor College of Medicine (United States)
Texas Children’s Hospital (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)
Samara State Aerospace Univ. (Russia)
Chandra Mohan, Univ. of Houston (United States)

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