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Journal of Biomedical Optics • Open Access

Craniofacial tissue oxygen saturation is associated with blood pH using an examiner’s finger-mounted tissue oximetry in mice
Author(s): Toshiyuki Uchida; Naohiro Kanayama; Kenta Kawai; Masatsugu Niwayama

Paper Abstract

Although fetal scalp blood sampling is an examination to assess fetal acidosis during the intrapartum period, it has not been widely used by obstetricians because of its invasiveness. We have developed a small, portable oximetry with a sensor attached to the examiner’s finger. Our previous report using this oximetry concluded that fetal head tissue oxygen saturation (StO2) correlated with umbilical cord artery blood pH. We investigated whether the association between StO2 and blood pH in mice could be validated using this oximetry. Eleven the Institute for Cancer Research (ICR) mice were measured using a near-infrared spectroscopy probe at the craniofacial site in a closed polyethylene bag while changing the oxygen concentration. A total of nine blood samples were collected and analyzed for pH. The StO2 and tissue blood pH showed a strong positive correlation (r=0.90 and P=0.0009). The StO2 and total hemoglobin index also showed a positive correlation (r=0.84 and P=0.0049). Thus, the results of the present study support those of our previous report on clinical cases and allow examiners to easily check the status of fetal acidosis. Fetal management using this oximetry might gain popularity with obstetricians in the near future.

Paper Details

Date Published: 12 April 2016
PDF: 3 pages
J. Biomed. Opt. 21(4) 040502 doi: 10.1117/1.JBO.21.4.040502
Published in: Journal of Biomedical Optics Volume 21, Issue 4
Show Author Affiliations
Toshiyuki Uchida, Hamamatsu Univ. School of Medicine (Japan)
Naohiro Kanayama, Hamamatsu Univ. School of Medicine (Japan)
Kenta Kawai, Hamamatsu Univ. School of Medicine (Japan)
Masatsugu Niwayama, Shizuoka Univ. (Japan)


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