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Journal of Biomedical Optics • Open Access

Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow

Paper Abstract

We demonstrate in vivo volumetric optical microangiography at ∼200  volumes/s by the use of 1.6 MHz Fourier domain mode-locking swept source optical coherence tomography and an effective 36 kHz microelectromechanical system (MEMS) scanner. We propose an intervolume analysis strategy to contrast the dynamic blood flow signal from the static tissue background. The proposed system is demonstrated by imaging cerebral blood flow in mice in vivo. For the first time, imaging speed, sensitivity, and temporal resolution become possible for a direct four-dimensional observation of microcirculations within live body parts.

Paper Details

Date Published: 11 March 2016
PDF: 6 pages
J. Biomed. Opt. 21(3) 036005 doi: 10.1117/1.JBO.21.3.036005
Published in: Journal of Biomedical Optics Volume 21, Issue 3
Show Author Affiliations
Wei Wei, Univ. of Washington (United States)
Jingjiang Xu, Univ. of Washington (United States)
Utku Baran, Univ. of Washington (United States)
Shaozhen Song, Univ. of Washington (United States)
Wan Qin, Univ. of Washington (United States)
Xiaoli Qi, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

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