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Journal of Biomedical Optics

Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy
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Paper Abstract

A combined diffuse speckle contrast analysis (DSCA)–near-infrared spectroscopy (NIRS) system is proposed to simultaneously measure qualitative blood flow and blood oxygenation changes in human tissue. The system employs an optical switch to alternate two laser sources at two different wavelengths and a CCD camera to capture the speckle image. Therefore, an optical density can be measured from two wavelengths for NIRS measurements and a speckle contrast can be calculated for DSCA measurements. In order to validate the system, a flow phantom test and an arm occlusion protocol for arterial and venous occlusion were performed. Shorter exposure times (<1  ms) show a higher drop (between 50% and 66%) and recovery of 1/KS2 values after occlusion (approximately 150%), but longer exposure time (3 ms) shows more consistent hemodynamic changes. For four subjects, the 1/KS2 values dropped to an average of 82.1±4.0% during the occlusion period and the average recovery of 1/KS2 values after occlusion was 109.1±0.8%. There was also an approximately equivalent amplitude change in oxyhemoglobin (OHb) and deoxyhemoglobin (RHb) during arterial occlusion (max RHb=0.0085±0.0024  mM/DPF, min OHb=−0.0057±0.0044  mM/DPF). The sensitivity of the system makes it a suitable modality to observe qualitative hemodynamic trends during induced physiological changes.

Paper Details

Date Published: 17 February 2016
PDF: 5 pages
J. Biomed. Opt. 21(2) 027001 doi: 10.1117/1.JBO.21.2.027001
Published in: Journal of Biomedical Optics Volume 21, Issue 2
Show Author Affiliations
Myeongsu Seong, Gwangju Institute of Science and Technology (Republic of Korea)
Zephaniah Phillips, Gwangju Institute of Science and Technology (Republic of Korea)
Phuong Minh Mai, Gwangju Institute of Science and Technology (Republic of Korea)
Chaebeom Yeo, DGIST (Republic of Korea)
Cheol Song, DGIST (Republic of Korea)
Kijoon Lee, DGIST (Republic of Korea)
Jae Gwan Kim, Gwangju Institute of Science and Technology (Korea, Republic of)


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