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Journal of Biomedical Optics

Laser speckle imaging based on photothermally driven convection
Author(s): Caitlin Regan; Bernard Choi
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Paper Abstract

Laser speckle imaging (LSI) is an interferometric technique that provides information about the relative speed of moving scatterers in a sample. Photothermal LSI overcomes limitations in depth resolution faced by conventional LSI by incorporating an excitation pulse to target absorption by hemoglobin within the vascular network. Here we present results from experiments designed to determine the mechanism by which photothermal LSI decreases speckle contrast. We measured the impact of mechanical properties on speckle contrast, as well as the spatiotemporal temperature dynamics and bulk convective motion occurring during photothermal LSI. Our collective data strongly support the hypothesis that photothermal LSI achieves a transient reduction in speckle contrast due to bulk motion associated with thermally driven convection. The ability of photothermal LSI to image structures below a scattering medium may have important preclinical and clinical applications.

Paper Details

Date Published: 26 February 2016
PDF: 5 pages
J. Biomed. Opt. 21(2) 026011 doi: 10.1117/1.JBO.21.2.026011
Published in: Journal of Biomedical Optics Volume 21, Issue 2
Show Author Affiliations
Caitlin Regan, Univ. of California, Irvine (United States)
Beckman Laser Institute and Medical Clinic (United States)
Bernard Choi, Univ. of California, Irvine (United States)
Beckman Laser Institute and Medical Clinic (United States)
CHOC Children's (United States)


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