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Journal of Biomedical Optics

Retinal optical coherence tomography at 1  μm with dynamic focus control and axial motion tracking
Author(s): Michelle Cua; Sujin Lee; Dongkai Miao; Myeong Jin Ju; Paul J. Mackenzie; Yifan Jian; Marinko V. Sarunic
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Paper Abstract

High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample arm optics. Retinal layer tracking and selection was performed using a graphics processing unit accelerated processing platform for focus optimization, providing real-time layer-specific en face visualization. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the retina and optic nerve head, from which we extracted clinically relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

Paper Details

Date Published: 15 February 2016
PDF: 8 pages
J. Biomed. Opt. 21(2) 026007 doi: 10.1117/1.JBO.21.2.026007
Published in: Journal of Biomedical Optics Volume 21, Issue 2
Show Author Affiliations
Michelle Cua, Simon Fraser Univ. (Canada)
Sujin Lee, Simon Fraser Univ. (Canada)
Dongkai Miao, Simon Fraser Univ. (Canada)
Myeong Jin Ju, Simon Fraser Univ. (Canada)
Paul J. Mackenzie, The Univ. of British Columbia (Canada)
Yifan Jian, Simon Fraser Univ. (Canada)
Marinko V. Sarunic, Simon Fraser Univ. (Canada)

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