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Journal of Biomedical Optics • Open Access

Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography
Author(s): Sripriya Ramamoorthy; Yuan Zhang; Tracy Petrie; Anders Fridberger; Tianying Ren; Ruikang K. Wang; Steven L. Jacques; Alfred L. Nuttall

Paper Abstract

Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100 to 500 Hz) are processed in the apex region. Among mammals, the guinea pig cochlear apex processes similar frequencies and is thus relevant for the study of speech processing in the cochlea. However, the requirement for extensive surgery has challenged the optical accessibility of this area to investigate cochlear processing of signals without significant intrusion. A simple method is developed to provide optical access to the guinea pig cochlear apex in two directions with minimal surgery. Furthermore, all prior vibration measurements in the guinea pig apex involved opening an observation hole in the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here, this limitation is overcome by measuring the vibrations through the unopened otic capsule using phase-sensitive Fourier domain optical coherence tomography. The optically and surgically advanced method described here lays the foundation to perform minimally invasive investigation of speech-related signal processing in the cochlea.

Paper Details

Date Published: 2 February 2016
PDF: 7 pages
J. Biomed. Opt. 21(2) 025003 doi: 10.1117/1.JBO.21.2.025003
Published in: Journal of Biomedical Optics Volume 21, Issue 2
Show Author Affiliations
Sripriya Ramamoorthy, Oregon Health & Science Univ. (United States)
Yuan Zhang, Oregon Health & Science Univ. (United States)
Tracy Petrie, Oregon Health & Science Univ. (United States)
Anders Fridberger, Linköping Univ. (Sweden)
Tianying Ren, Oregon Health & Science Univ. (United States)
Ruikang K. Wang, Univ. of Washington (United States)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Alfred L. Nuttall, Oregon Health & Science Univ. (United States)
Univ. of Michigan (United States)

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