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Journal of Biomedical Optics

Disposable sheath that facilitates endoscopic Raman spectroscopy
Author(s): Wenbo Wang; Michael A. Short; Isabella T. Tai; Haishan Zeng
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Paper Abstract

<italic<In vivo</italic< endoscopic Raman spectroscopy of human tissue using a fiber optic probe has been previously demonstrated. However, there remain several technical challenges, such as a robust control over the laser radiation dose and measurement repeatability during endoscopy. A decrease in the signal to noise was also observed due to aging of Raman probe after repeated cycles of harsh reprocessing procedures. To address these issues, we designed and tested a disposable, biocompatible, and sterile sheath for use with a fiber optic endoscopic Raman probe. The sheath effectively controls contamination of Raman probes between procedures, greatly reduces turnaround time, and slows down the aging of the Raman probes. A small optical window fitted at the sheath cap maintained the measurement distance between Raman probe end and tissue surface. To ensure that the sheath caused a minimal amount of fluorescence and Raman interference, the optical properties of materials for the sheath, optical window, and bonding agent were studied. The easy-to-use sheath can be manufactured at a moderate cost. The sheath strictly enforced a maximum permissible exposure standard of the tissue by the laser and reduced the spectral variability by 1.5 to 8.5 times within the spectral measurement range.

Paper Details

Date Published: 1 February 2016
PDF: 6 pages
J. Biomed. Opt. 21(2) 025001 doi: 10.1117/1.JBO.21.2.025001
Published in: Journal of Biomedical Optics Volume 21, Issue 2
Show Author Affiliations
Wenbo Wang, BC Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada)
Michael A. Short, BC Cancer Research Ctr. (Canada)
Isabella T. Tai, BC Cancer Research Ctr. (Canada)
The Univ. of British Columbia (Canada)
Haishan Zeng, BC Cancer Research Ctr. (Canada)

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