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Journal of Biomedical Optics

Photoacoustic microscopy of arteriovenous shunts and blood diffusion in early-stage tumors
Author(s): Chenghung Yeh; Jinyang Liang; Yong Zhou; Song Hu; Rebecca E. Sohn; Jeffrey M. Arbeit; Lihong V. Wang
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Paper Abstract

Angiogenesis in a tumor region creates arteriovenous (AV) shunts that cause an abnormal venous blood oxygen saturation (sO2) distribution. Here, we applied optical-resolution photoacoustic microscopy to study the AV shunting in vivo. First, we built a phantom to image sO2 distribution in a vessel containing converged flows from two upstream blood vessels with different sO2 values. The phantom experiment showed that the blood from the two upstream vessels maintained a clear sO2 boundary for hundreds of seconds, which is consistent with our theoretical analysis using a diffusion model. Next, we xenotransplanted O-786 tumor cells in mouse ears and observed abnormal sO2 distribution in the downstream vein from the AV shunts in vivo. Finally, we identified the tumor location by tracing the sO2 distribution. Our study suggests that abnormal sO2 distribution induced by the AV shunts in the vessel network may be used as a new functional benchmark for early tumor detection.

Paper Details

Date Published: 16 February 2016
PDF: 4 pages
J. Biomed. Opt. 21(2) 020501 doi: 10.1117/1.JBO.21.2.020501
Published in: Journal of Biomedical Optics Volume 21, Issue 2
Show Author Affiliations
Chenghung Yeh, Washington Univ. in St. Louis (United States)
Jinyang Liang, Washington Univ. in St. Louis (United States)
Yong Zhou, Washington Univ. in St. Louis (United States)
Song Hu, Univ. of Virginia (United States)
Rebecca E. Sohn, Washington Univ. School of Medicine in St. Louis (United States)
Jeffrey M. Arbeit, Washington Univ. School of Medicine in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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