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Journal of Biomedical Optics

Sensitized TiO2 nanocomposites through HMME linkage for photodynamic effects
Author(s): Yu Lu He; Sijia Wang; Luwei Zhang; Jing Xin; Jing Wang; Cuiping Yao; Zhenxi Zhang; Chih-Chung Yang
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Paper Abstract

Although TiO2 can be used to effectively generate reactive oxygen species (ROS) for photodynamic application, its absorption in the ultraviolet range makes the excitation harmful to tissue. Based on the concept of a sensitized solar cell, TiO2 nanoparticles (NPs) are sensitized by linking with the photosensitizer, HMME, to form HMME-TiO2 nanocomposites (NCs) for demonstrating the photodynamic effects under the illumination of white light. The HMME-TiO2 NCs of different composition ratios are prepared for maximizing the generation of ROS and optimizing the inactivation effect of KB cells. The material characteristics and the ROS generation capability of the HMME-TiO2 NCs with the optimized combination ratio show their merits in a photodynamic process under white light irradiation. The application of such NCs to KB cell experiments results in a higher inactivation efficiency when compared to pure HMME of the same concentration.

Paper Details

Date Published: 15 December 2016
PDF: 9 pages
J. Biomed. Opt. 21(12) 128001 doi: 10.1117/1.JBO.21.12.128001
Published in: Journal of Biomedical Optics Volume 21, Issue 12
Show Author Affiliations
Yu Lu He, Xi'an Jiaotong Univ. (China)
Sijia Wang, Xi'an Jiaotong Univ. (China)
Luwei Zhang, Xi'an Jiaotong Univ. (China)
Jing Xin, Xi'an Jiaotong Univ. (China)
Jing Wang, Xi'an Jiaotong Univ. (China)
Cuiping Yao, Xi'an Jiaotong Univ. (China)
Zhenxi Zhang, Xi'an Jiaotong Univ. (China)
Chih-Chung Yang, National Taiwan Univ. (Taiwan)

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