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Journal of Biomedical Optics

Diffuse shear wave imaging: toward passive elastography using low-frame rate spectral-domain optical coherence tomography
Author(s): Thu-Mai Nguyen; Ali Zorgani; Maxime Lescanne; Claude Boccara; Mathias Fink; Stefan Catheline
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Paper Abstract

Optical coherence tomography (OCT) can map the stiffness of biological tissue by imaging mechanical perturbations (shear waves) propagating in the tissue. Most shear wave elastography (SWE) techniques rely on active shear sources to generate controlled displacements that are tracked at ultrafast imaging rates. Here, we propose a noise-correlation approach to retrieve stiffness information from the imaging of diffuse displacement fields using low-frame rate spectral-domain OCT. We demonstrated the method on tissue-mimicking phantoms and validated the results by comparison with classic ultrafast SWE. Then we investigated the in vivo feasibility on the eye of an anesthetized rat by applying noise correlation to naturally occurring displacements. The results suggest a great potential for passive elastography based on the detection of natural pulsatile motions using conventional spectral-domain OCT systems. This would facilitate the transfer of OCT-elastography to clinical practice, in particular, in ophthalmology or dermatology.

Paper Details

Date Published: 21 December 2016
PDF: 8 pages
J. Biomed. Opt. 21(12) 126013 doi: 10.1117/1.JBO.21.12.126013
Published in: Journal of Biomedical Optics Volume 21, Issue 12
Show Author Affiliations
Thu-Mai Nguyen, Institut Langevin (France)
Ali Zorgani, LabTAU (France)
Maxime Lescanne, LabTAU (France)
Claude Boccara, Institut Langevin (France)
Mathias Fink, Institut Langevin (France)
Stefan Catheline, LabTAU (France)


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