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Journal of Biomedical Optics

Noninvasive in vivo multispectral optoacoustic imaging of apoptosis in triple negative breast cancer using indocyanine green conjugated phosphatidylserine monoclonal antibody
Author(s): Ravi Kumar Kannadorai; Sunil Kumar Udumala; Sidney Yu Wing Kwok
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Paper Abstract

Noninvasive and nonradioactive imaging modality to track and image apoptosis during chemotherapy of triple negative breast cancer is much needed for an effective treatment plan. Phosphatidylserine (PS) is a biomarker transiently exposed on the outer surface of the cells during apoptosis. Its externalization occurs within a few hours of an apoptotic stimulus by a chemotherapy drug and leads to presentation of millions of phospholipid molecules per apoptotic cell on the cell surface. This makes PS an abundant and accessible target for apoptosis imaging. In the current work, we show that PS monoclonal antibody tagged with indocyanine green (ICG) can help to track and image apoptosis using multispectral optoacoustic tomography

Paper Details

Date Published: 1 December 2016
PDF: 6 pages
J. Biomed. Opt. 21(12) 126002 doi: 10.1117/1.JBO.21.12.126002
Published in: Journal of Biomedical Optics Volume 21, Issue 12
Show Author Affiliations
Ravi Kumar Kannadorai, Singapore General Hospital (Singapore)
Sunil Kumar Udumala, Singapore General Hospital (Singapore)
Sidney Yu Wing Kwok, Singapore General Hospital (Singapore)

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