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Journal of Biomedical Optics • Open Access

Language mapping in children using resting-state functional connectivity: comparison with a task-based approach
Author(s): Anne Gallagher; Julie Tremblay; Phetsamone Vannasing

Paper Abstract

Patients with brain tumor or refractory epilepsy may be candidates for neurosurgery. Presurgical evaluation often includes language investigation to prevent or reduce the risk of postsurgical language deficits. Current techniques involve significant limitations with pediatric populations. Recently, near-infrared spectroscopy (NIRS) has been shown to be a valuable neuroimaging technique for language localization in children. However, it typically requires the child to perform a task (task-based NIRS), which may constitute a significant limitation. Resting-state functional connectivity NIRS (fcNIRS) is an approach that can be used to identify language networks at rest. This study aims to assess the utility of fcNIRS in children by comparing fcNIRS to more conventional task-based NIRS for language mapping in 33 healthy participants: 25 children (ages 3 to 16) and 8 adults. Data were acquired at rest and during a language task. Results show very good concordance between both approaches for language localization (Dice similarity coefficient = 0.81 ± 0.13 ) and hemispheric language dominance ( kappa = 0.86 , p < 0.006 ). The fcNIRS technique may be a valuable tool for language mapping in clinical populations, including children and patients with cognitive and behavioral impairments.

Paper Details

Date Published: 19 December 2016
PDF: 8 pages
J. Biomed. Opt. 21(12) 125006 doi: 10.1117/1.JBO.21.12.125006
Published in: Journal of Biomedical Optics Volume 21, Issue 12
Show Author Affiliations
Anne Gallagher, CHU Sainte-Justine (Canada)
Univ. de Montréal (Canada)
Julie Tremblay, CHU Sainte-Justine (Canada)
Univ. de Montréal (Canada)
Phetsamone Vannasing, CHU Sainte-Justine (Canada)
Univ. de Montréal (Canada)

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