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Journal of Biomedical Optics

Early discrimination of nasopharyngeal carcinoma based on tissue deoxyribose nucleic acid surface-enhanced Raman spectroscopy analysis
Author(s): Sufang Qiu; Chao Li; Jinyong Lin; Yuanji Xu; Jun Lu; Qingting Huang; Changyan Zou; Chao Chen; Nanyang Xiao; Duo Lin; Rong Chen; Jianji Pan; Shangyuan Feng
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Paper Abstract

Surface-enhanced Raman spectroscopy (SERS) was employed to detect deoxyribose nucleic acid (DNA) variations associated with the development of nasopharyngeal carcinoma (NPC). Significant SERS spectral differences between the DNA extracted from early NPC, advanced NPC, and normal nasopharyngeal tissue specimens were observed at 678, 729, 788, 1337, 1421, 1506, and 1573  cm−1, which reflects the genetic variations in NPC. Principal component analysis combined with discriminant function analysis for early NPC discrimination yielded a diagnostic accuracy of 86.8%, 92.3%, and 87.9% for early NPC, advanced NPC, and normal nasopharyngeal tissue DNA, respectively. In this exploratory study, we demonstrated the potential of SERS for early detection of NPC based on the DNA molecular study of biopsy tissues.

Paper Details

Date Published: 9 December 2016
PDF: 6 pages
J. Biomed. Opt. 21(12) 125003 doi: 10.1117/1.JBO.21.12.125003
Published in: Journal of Biomedical Optics Volume 21, Issue 12
Show Author Affiliations
Sufang Qiu, Fujian Medical Univ. (China)
Fujian Provincial Key Lab. of Translational Cancer Medicine (China)
Chao Li, Fujian Medical Univ. (China)
Jinyong Lin, Fujian Medical Univ. (China)
Yuanji Xu, Fujian Medical Univ. (China)
Jun Lu, Fujian Medical Univ. (China)
Qingting Huang, Fujian Medical Univ. (China)
Changyan Zou, Fujian Medical Univ. (China)
Chao Chen, Fujian Medical Univ. (China)
Nanyang Xiao, Fujian Normal Univ. (China)
Duo Lin, Fujian Normal Univ. (China)
Fujian Univ. of Traditional Chinese Medicine (China)
Rong Chen, Fujian Normal Univ. (China)
Jianji Pan, Fujian Medical Univ. (China)
Fujian Provincial Key Lab. of Translational Cancer Medicine (China)
Shangyuan Feng, Fujian Normal Univ. (China)


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